摘要
目的探讨hMLH1、hMSH2蛋白在口腔鳞状细胞癌组织中的表达及意义。方法采用免疫组化法检测69例口腔鳞状细胞癌和40例正常口腔粘膜组织中hMLH1、hMSH2的表达情况,资料的统计学处理用SPSS软件完成,比较用卡方检验。结果口腔鳞状细胞癌组织中hMLH1、hMSH2的阳性表达率(47.8%,55.1%)低于正常口腔粘膜组织(77.5%,80.0%),P<0.05,有显著差异。hMLH1、hMSH2的表达与年龄、性别无关(P>0.05),而与分化程度有关,分化程度越低,hMLH1、hMSH2失表达越明显,P<0.05。结论MLH1、hMSH2的表达只与分化程度相关,随分化程度的降低,其失表达越明显。
Objective To study the expression and significance of hMLH1, hMSH2 in oral squamous cell carcinoma （OSCC）. Methods The expression of hMLH1 and hMSH2 in 69 cases of OSCC and 40 normal oral mucosa was examined by immunohistochemical methed. The data was analyzed by Chi-square test. Results Positive rates of hMLH1 and hMSH2 were lower in OSCC （47.8% and 55.1% respectively） than in normal oral mucosa （ 77.5% and 80.0% respectively）. These differences between OSCC and normal oral mucosa were statistically significant （P 〈 0. 05 ）. The expression of hMLHland hMSH2 was not significantly correlated with age and sex of patients （P 〉 0. 05 ） but associated with differentiation of the lesion, the poor the differentiation, the less the expression. Conclusion The expression of hMLHland hMSH2 was correlated with differentiation.
出处
《北京口腔医学》
CAS
2007年第2期87-90,共4页
Beijing Journal of Stomatology
基金
河北省科技厅计划内课题(NO.:052761746)
