摘要
目的探讨利培酮与氯氮平对女性首发精神分裂症患者血脂的影响。方法将55例女性首发精神分裂症患者随机分为利培酮组25例,氯氮平组30例,于治疗前及治疗8周末检测血脂水平并进行比较。结果氯氮平组治疗后甘油三脂(TG)、总胆固醉(TC)、低密度脂蛋白胆固醇(LDL)、载脂蛋白B(APOB)明显升高(P<0.05),高密度脂蛋白胆固醇(HDL)明显降低,利培酮组治疗后TG、APOB明显升高,而TC、LDL、HDL治疗前后无明显变化。结论利培酮、氯氮平均可导致女性首发精神分裂症患者的血脂异常。利培酮较氯氮平对血脂影响较小。临床用药时应注意监测血脂的变化,及早采取相应的预防措施。
Objective To study the effects of risperidone and clozapine on lipometabolism in female first-episode schizophrenia patients. Methods 55 female first-episode schizophrenia patients were randomly divided into two groups, 25 patients treated with risperidone and 30 patients treated with clozapine. Lipometabolism levels were measured before treament and at the end of 8 weeks. Results Triglyceride （TG）, total cholesterol （TC）, low density lipoprotein （LDL）, apolipoproteinB （apoB） were significantly higher （P〈0.05） and high density lipoprotein （HDL） was significantly lower after receiving clozapine; TG, apoB were significantly higher, but TC, LDL, HDL were no significant change after receiving risperidone. Conclusion Risperidone and clozapine may also result in abnormal lipometabolism levels. Effect of risperidone on lipometabolism was less than of clozapine. When clinical treatment, change of lipometabolism should be monitored, and precaution measures can be adopted early.
出处
《中国健康心理学杂志》
2007年第4期359-360,共2页
China Journal of Health Psychology
关键词
利培酮
氯氮平
血脂
精神分裂症
Risperidone
Clozapine
Lipometabolism
Schizophrenia
