摘要
目的:探讨奎硫平与氯丙嗪对精神分裂症患者血清催乳素(PRL)的影响及血清PRL水平与药物疗效的相互关系。方法:对191例精神分裂症患者分别以奎硫平或氯丙嗪治疗。以阳性与阴性症状量表(PANSS)进行评估,同时测血清PRL浓度,于治疗前及治疗8周时各测1次。结果:经8周治疗,氯丙嗪组血清PRL(680.23±90.26)μg/L,显著高于奎硫平组(124.24±13.56)μg/L(P<0.001)。奎硫平组男女患者血清PRL水平差异无显著性(P>0.05);氯丙嗪组女性血清PRL(785.72±15.81)μg/L,显著高于男性的(557.75±99.23)μg/L(P<0.05),两组患者血清PRL浓度与PANSS减分率均无显著相关。结论:奎硫平对精神分裂症患者血清PRL水平基本无影响,氯丙嗪可明显升高患者血清PRL水平。血清PRL水平与药物疗效无显著相关。
Objective：To explore the effects on serum prolactin（PRL） of seroquel and chlorpromazine in the treatment of schizophrenic patients. Method： 191 schizophrenic patients were treated with seroquel or chlorpromazine randomly. The efficacy was measured with the positive and negative symptoms scale before treatment and at the 8th week respectively, while the level of serum PRL were measured. Results：The level of serum PRL in chlorpromazine group（680.23 ± 90.26）μg/L increased markedly than seroquel group （ 124.24 ± 13.56）μg/L（ P 〈 0.001 ）, and the level of serum PRL of female patients with chlorpromazine （785.72 ± 15.81 ）μg/L were much more than that of male patients （557.75 ± 99.23）μg/L（ P 〈 0.05） .The serum PRL level in two groups were not related with the reduction of PANSS scores. Condusion：Serequel has less effect on the level of serum PRL in schizophrenic patients, chlorpromazine increases the serum PRL concentrations significantly. Both drugs＇ effect are not related with serum PRL.
出处
《临床精神医学杂志》
2005年第4期212-213,共2页
Journal of Clinical Psychiatry
