摘要
本文对照组织学应用银染技术对49例病人胃镜刷检细胞进行了核仁组成区相关嗜银蛋白定量研究。其中腺癌16例、鳞癌21例、非典型增生5例、慢性炎症7例。结果表明，随鳞状上皮病变级别增高，AgNoRs均数也逐级增高；腺癌细胞AgNoRs均数明显高于正常腺上皮细胞（P＜0．05）；正常细胞与癌细胞AgNoRs数目、形态、大小及分布都有显著差异。应用AgNoRs染色观察，使细胞学与组织学的诊断符合率由原来的75．51％提高到83．67％。表明AgNoRs在胃镜刷检细胞学中，同样是反映细胞增殖水平的敏感指标，尤其在大规模的细胞学普查中，可能有较大的实用价值。
Smers of gastroscope-brushing Cytology in 49 patients were examined with Argyrophilic nucleolar organizer region stain technique, the final diagnoses were based on the pareffin-embowered tissue sections, among which 16 adenocarcinomas,21 squamous cell carcinomas 5 atypical dysplasias and 7 chronic inflammations. Rsseults showed that the mean number of AgNoR. increased in proportion to the seventy of lesion of the squamous cells; and more AgNoRs in adenocarcinoma cell than that in normal glandular epithelium cell were observed (P＜0. 05); Agnors in cancer cell are different from that in normal cells in amount, shage, size and disstribution within nucleus. The Conformance rate of cytology to histology increased from 75. 51% to 83.67 % by means of AgNoRs determination. It suggested that AgNoRs is a comparatively senstive index to reflect proliferative activity of cells in gastroscope-brushing cytology. and may apply more practical utilization to general survey of esophgeal and gastric diseases.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1997年第1期24-26,共3页
Cancer Research on Prevention and Treatment
关键词
核仁组成区
细胞学
腺癌
鳞癌
胃镜检
nucleolar organizer region
cytology
adenocarcinoma
squamous cell carcinoma
atypical dysplasia
