摘要
哺乳动物下丘脑视交叉上核（ＳＣＮ）在昼夜节律的发生和调节中起着非常重要的作用。它大量接受来自中缝背核（ＤＲ）神经元的神经支配。本实验结果表明，不论在正常光照条件下，或者在连续光照和连续黑暗条件下，损毁ＤＲ后，小鼠踏转轮运动的昼夜节律消失；注射５—ＨＴ台成抑制剂对氯苯百氨酸后，踏转轮运动的节律也消失，但在注射后第７天起开始恢复。结果提示，从ＤＲ到ＳＣＮ的５－ＨＴ能神经传递可能参与踏转轮活动的昼夜节律调节。
The suprachiasmatic nucleus (SCN) of the hypothalamus plays a critical role in the generation and regulation of circadian rhythms in mammals. It receives a dense innervation from cells located primarily in the dorsal raphe nucleus (DR). The results of the present experiments demonstrated that under normal light/ dark cycle (LD) and constant light (LL) or constant darkness (DD) the wheel running circadian rhythm in mice disappeared after DR lesion, as well as after para-chlorophenylalanine (PCPA) injection (i.p.). PCPA-induced disruption of the circadian rhythm began to recover on the 7 th day after injection. It is suggested that the serotonergic neurotransmission from DR to SCN might he involved in the circadian rhythm regulation of wheel running activity.
出处
《神经科学》
SCIE
CAS
1996年第3期134-138,共5页
Chinese Journal of Neuroscience
基金
国家自然科学基金
关键词
昼夜节律
中缝背核
对氯苯丙氨酸
转轮
circadian rhythm
dorsal raphe nucleus
para-chlorophenylalanine
running wheel
5--hydroxytryptamine
