摘要
以丙氨酸、苯丙氨酸为手性起始试剂,对其氨基进行了叔丁氧羰酰基保护,然后将其与丙烯醇进行酯化反应,该酯化反应以4-二甲氨基吡啶(DMAP)和N,N-二环己基碳二亚胺(DCC)为偶联剂,反应条件温和,不会造成氨基酸的外消旋化反应,对制备出的带有双键的可聚合反应手性单体进行了结构表征,为下一步进行手性聚合反应打下了基础。
N-（ tert-butoxy carbonyl ） -L- alanine and N-（ tert-butoxy carbonyl） -L-phenylalanine were synthesized via carbolylation of L-alanine and L-phenylalanine with Di-tert-butyl dicarhonate. And then the chiral monomers of N-acyl amino acid esters were synthesisedvia esterification of Boc-L-amino acid, mentioned above, with acryl alcohol catalyzed by 4-dimethylamino pyridine and 1,3-dicyclohexylcarbodiimide. The structure and properties of the products were studied.
基金
国家自然科学基金资助项目(20374035)
