摘要
目的:探讨促血管生成素-2在子宫内膜异位症患者异位和在位子宫内膜组织中的表达,及其在子宫内膜异位症发病中的作用。方法:采用免疫组织化学方法检测30例子宫内膜异位症患者的异位内膜和在位内膜组织及30例正常对照组内膜组织中促血管生成素-2的表达。结果:在位内膜组织中促血管生成素-2的表达高于对照组和异位内膜组,差异有统计学意义(P<0．05),异位内膜组高于对照组,差异亦有统计学意义(P<0．05)。在位内膜组和对照组的不同月经周期促血管生成素-2的表达差异有统计学意义(P<0．05)。结论:促血管生成素-2在子宫内膜异位症组织中的高表达可能与子宫内膜异位症的发生、发展及血管生成密切相关。
Objective To investigate the expression of angiopoietin-2 in eutopic and ectopic endometrium of patients with endometriosis. Methods Immunochemical method was used to determine the expression of angiopoietin-2 in 40 cases of eutopic and ectopic endometrium with endometriosis and 30 cases of endometrium without endometriosis. Results The expression of angiopoietin-2 in eutopic endometrium of ovarian endometriosis was higher than that of normal endometrium（P〈0. 05）. There was a statistic difference between secretory phase andproliferative phase in the groups of eutopic and normal endometrium. Conclusion Angiopoietin-2 plays a significant role in the regulation of angiogenesis of endomentrionsis which is overexpressed in endometriosis. Angiopoietin-2 may play a vital role in the pathogenesis and development of endometriosis.
出处
《实用诊断与治疗杂志》
2007年第4期271-272,共2页
Journal of Practical Diagnosis and Therapy
