摘要
目的探讨p73、p53蛋白在胃癌中的表达及其与临床病理特征的关系。方法应用免疫组织化学方法检测42例胃癌、22例慢性浅表性胃炎、26例慢性萎缩性胃炎、19例胃溃疡和20例胃黏膜异型增生中的p73、p53蛋白的表达情况,并结合临床病理资料进行统计学分析。结果胃癌中p73、p53蛋白的阳性表达率分别为40.48%、54.76%,与慢性浅表性胃炎、慢性萎缩性胃炎、胃溃疡和胃黏膜异型增生相比,差异有统计学意义(P<0.05);p53蛋白表达与胃癌的组织分化程度、黏膜浸润深度、淋巴结转移相关(P<0.05);p73蛋白表达与胃癌的组织分化程度相关(P<0.05),与黏膜浸润深度、淋巴结转移无相关(P>0.05);胃癌组织中p73、p53蛋白表达之间呈正相关(P<0.05)。结论p73、p53蛋白在胃癌组织中呈高水平表达,二者可能共同参与了胃癌的发生发展过程。
Objective To study the expression of p73 ,p53 protein in gastric carcinoma and relationship between their expression and clinic pathological characteristics. Methods Immunohistochemical method was used to detect the expression of p73, p53 protein in 42 cases of gastric carcinoma, 22 chronic superficial gastritis, 26 chronic atrophic gastritis, 19 gastric ulcer and 20 atypical hyperplasia. The data of these protein expression and clinic pathological observation were statistically analyzed. Resuits The ,positive rates of expression of p73 and p53 protein in gastric carcinoma were 40.48% and 54.76% respectively. Compared with those in chronic superficial gastritis group, chronic atrophic gastritis group, gastric ulcer group and atypical hyperplasia group, the statistical difference was significant （ P 〈 0.05 ）. The expression rate of p53 protein was positively related with the differentiation of gastric cancer, depth of invasion of gastric mucosa, lymph node metastasis （P 〈 0.05 ）. The expression rate of p73 protein was positively related with differentiation of gastric cancer（ P 〈 0.05 ）. No significant relationship was observed between p73 protein expression and depth of invasion of gastric mucosa and lymph node metastasis（ P 〉 0.05） ;The positive correlation was present between p73 and p53 protein expression in gastric cancer. Conclusions Expression of p73 and p53 protein was obvious high in gastric cancer. Perhaps Both of p73 and p53 protein participate in the development of gastric cancer .
出处
《实用全科医学》
2007年第4期317-318,F0003,共3页
Applied Journal Of General Practice
