摘要
目的:观察连柏液在预防和治疗急性放射性皮肤损伤中的作用.方法:2000-05/2005-12治疗的126例恶性肿瘤患者随机分为2个组,75例在第1次放射治疗后给予连柏液外涂为预防组,51例只做常规放射治疗宣教和健康教育为对照1组.将同期出现3级急性放射性皮肤损伤的92例患者随机分成治疗组54例,对照2组常规治疗38例.根据NCI制定的CTC.V2.0急性放射性皮肤损伤的分级标准进行临床评价.结果:皮肤反应发生率预防组和对照1组分别为32.0%,92.2%,差异有统计学意义(u=6.769,P<0.01).轻度放射反应(1+2级)预防组为28.0%(21/75),对照1组为70.6%(36/51),两组比较差异有统计学意义(χ2=22.226,P<0.01).3级急性放射性皮肤损伤患者治疗组和对照2组的有效率分别为92.6%(50/54)和65.9%(25/38),两组比较差异有统计学意义(χ2=6.018,P=0.024).治疗组创面愈合时间(11.07±2.21)d;对照2组愈合时间(18.08±1.76)d,二者差异有统计学意义(u=16.932,P<0.01).结论:连柏液能有效地预防放射性皮炎的发生,治疗3级急性放射性皮肤损伤疗效明显.连柏液疗效安全可靠,经济,使用方便,对患者能减轻痛苦、提高生活质量、保证放射治疗的顺利进行.
AIM： To observe the clinical effect of lianbai liquid in the prevention and treatment of irradiation-induced acute dermal injury. METHODS： The carcinoma patients（n = 126） who had to accept radiotherapy from May, 2000 to December, 2005, were randomized into 2 groups ： prevention group （ n = 75 ） was given lianbai liquid since the 1st radiotherapy session , and control group 1 （ n = 51 ） was given only general and health education program without lianbai liquid application. Other 92 cases of 3- grade radiation-induced dermatitis were randomly divided into 2 groups （n = 54 in treatment group, n = 38 in control group 2）. The evaluation of radiation-induced acute dermatitis was done according to CTC. V2. 0 proposed by NCI. RESULTS： Skin reaction rate and grade in the prevention group（ 32.0% ） was obviously lower than that of the control group 1 （92. 2% ） （ u = 6. 769, P 〈 0.01）. The mild radiation reaction（1 ±2 grade）rate in the prevention group（28.0% ） was obviously lower than that of the control group 1 （70.6%）, with significant difference between the 2 groups （Х^2 = 22. 226, P 〈 0. 01 ）. The effective rate of 3 grade acute radiation-induced dermatitis in treatment group was 92.6% （50/54） ,better than that in control group 2 （65.9%, 25/38） （Х^2= 6. 018, P = 0. 024）. The healing time of 3 grade radiationinduced dermatitis was （11.07 ±2.21）d in the treatment groups and was obviously shorter than that of the control group 2 （ 18.08 ± 1.76） d （ u = 16.932, P 〈 0. 01 ）. CONCLUSION： Lianbai liquid can effectively prevent irradiation-induced acute dermal injury and treat the 3 grade radiation-induced acute skin injury. The application of lianbai liquid is safe, economic and convenient. It can alleviate the patients＇ suffering and improve their quality of life.
出处
《第四军医大学学报》
CAS
北大核心
2007年第6期509-511,共3页
Journal of the Fourth Military Medical University
关键词
黄连
黄柏
放射性皮炎
coptidis rhizoma
cortex phellodendri
radiodermatitis
