摘要
目的通过五龙颗粒对脾虚型变态反应性鼻炎(AR)大鼠白细胞介素-2、4、6 mRNA表达影响的研究,为健脾益气固表的五龙颗粒治疗AR提供理论依据。方法采用病证结合的方法造模,用RT-PCR法检测鼻黏膜白细胞介素mRNA的表达。结果五龙颗粒对实验性AR大鼠鼻黏膜处白细胞介素-2、4、6 mRNA的表达具有调节作用,升高的白细胞介素-4、6下降,降低的白细胞介素-2恢复。结论五龙颗粒可能通过调节细胞因子白细胞介素-2、4、6 mRNA的表达,对实验性AR大鼠发挥治疗作用。
Objective To study the effect of Wulong granules on the expression of IL-2 mRNA, IL-4 mRNA and IL-6 mRNA in allergic rhinitis （AR） rats in Spleen Qi deficiency type. To establish the clinic treatment principle-tonify Spleen and reinforce Qi of AR through the lab study. Methods Established AR model with combination of disease and Zheng, checked the expression of IL-2 mRNA, IL-4 mRNA and IL-6 mRNA of nasal mucosa were detected with RT-PCR. Results Wulong granules can adjust the expression of mRNA of AR rats＇ nasal mucosa. It can descend the ascensus of IL-4 mRNA, IL-6 mRNA and the drop of IL-2 mRNA. Conclusion Wulonggranules can show treatment effect to AR rats through adjusting the expression of cell factors such as IL-2 mRNA, IL-4 mRNA and IL-6 mRNA.
出处
《中国中医药信息杂志》
CAS
CSCD
2007年第3期28-30,共3页
Chinese Journal of Information on Traditional Chinese Medicine
