摘要
目的:探讨p16INK4A在宫颈癌早期及癌前病变中的表达,以及临床、病理分级间的相关性,寻找一种发现宫颈癌早期及癌前病变的新途径。方法:应用免疫组织化学方法(S-P法)检测p16INk4A在30例正常宫颈组织、40例慢性宫颈炎、100例宫颈上皮内瘤样病变(CIN)及107例宫颈鳞癌中的表达。结果:p16INk4A在上述五种组织中均有表达,且表达阳性率逐渐降低,分别为93.33%、90.00%、60.00%、44.86%,且其表达与宫颈癌病理分级、临床分期、淋巴转移有关。结论:p16INk4A的表达与宫颈癌的发生、发展有关,p16INK4A不仅为细胞周期的固有调控者,亦有可能在其他方面影响细胞生物学行为。
Objective： To study the expression of P16^INk4A in cervical cancer and pre -malignant lesion. To analysis its relationship with clinical and pathological character. Methods： We chose normal cervix 30 eases, chronic eervieitis 40 eases, CIN 100 eases and cervical aqueous cancer 107 eases P 16 INK4A of these tissues were examined with immunohistochemistry （S -P method） . Results： P 16^ INK4Awas expressed in all the four types of tissue. The expression rate decreased gradually. The positive rates of them were 99. 33%, 90. 00%, 60. 00% and 44. 86%, respectively. The expression related with the tumor cell differentiation, clinical stage and lymph node transplantation. Conclusion： The expression of P 16 ^INK4A is related with the arise and progression of cervical cancer. P 16 INK4A not only acts as a controller of cell cycle, but also may affect the biological action of cells in other ways.
出处
《中国妇幼保健》
CAS
北大核心
2007年第7期918-919,共2页
Maternal and Child Health Care of China
基金
广东省深圳市宝安区2003年第二批科技项目(No.2003190)
