摘要
目的 :探讨宫颈癌组织中HIF-1α的表达与宫颈癌之间的关系。方法 :采用免疫组化法检测177例分期为pT1b的宫颈癌患者宫颈组织(观察组)及100例正常宫颈组织(对照组)中HIF-1α的表达。结果 :宫颈癌患者宫颈组织中HIF-1α的阳性率表达高达79.7%,对照组宫颈组织中HIF-1α的阳性率表达为0。提示HIF-1α可作为宫颈癌早期筛查和诊断的一个重要参考标准。结论 :在宫颈癌早期存在着HIF-1α的高表达,因此,HIF-1α可作为宫颈癌早期筛查和诊断的一个重要参考标准。
Objective：To study relationship between the cervical cancer and HIF-1α expression. Methods： 177 cases of cervical cancer patients at pTlh stage were detected HIF-1α expression by immunohistochemical method （ the observation group ） and 100 cases with normal cervical tissue （ the control group ） were also detected the HIF expression. Results ： HIF-1α expression in patients with cervical cancer was as high as 79.7%, in the control group it was O. It indicated that HIF-1α. can be used as an important reference standard for cervical cancer screening and early diagnosis. Conclusion： In early stage of cervical cancer, there is HIF-1α high expression, therefore, HIF-1αcan be used as an important reference standard for cervical cancer screening and early diagnosis.
出处
《辽宁中医药大学学报》
CAS
2013年第2期130-131,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
陕西省科学技术研究发展计划项目(2011K13-02-06)
陕西省教育厅专项科研计划项目(2010JK911)
陕西省卫生厅卫生科研基金项目(2010H24)
延安市科技发展计划项目(2009KS-14)
延安大学自然科学专项科研基金项目(YD2010-06)
延安大学自然科学专项基金项目(YD2011-05)
关键词
宫颈癌组织
HIF-1Α
免疫组化法
高表达
cervical cancer tissue
HIF-1α
immunohistochemical method
high expression
