摘要
目的观察浸浴结合人工生物敷料和重组牛成纤维细胞生长因子2（rb-FGF2）治疗烧伤后期残余创面的效果。方法将有烧伤后期残余创面的56例患者分为试验组（28例）和对照组（28例）。试验组患者浸浴后，将生物敷料覆盖于创面行半暴露疗法，用rb-FGF2喷湿敷料2次／d，每2～3天浸浴1次并更换敷料；对照组刨面消毒后仅以单层碘伏纱布覆盖行半暴露疗法。1个疗程（10d）结束后，比较两组患者的治愈率、有效率、创面细菌学情况及相关安全性指标。结果试验组和对照组患者的治愈率、有效率、细菌清除率分别为64．3％、89．3％、92．3％和32．1％、67．9％、72．0％，两组上述指标比较，差异均有统计学意义（P＜0．01）。两组患者未发生不良反应。结论浸浴结合应用新型人工生物敷料和rb-FGF2治疗烧伤后期残余创面安全、有效，可控制创面感染、提高治愈率。
Objective To observe the effect of application of a new type of artificial biological dressing and recombinant bull fibroblast growth factor（rb-FGF2） after immersion bath in the treatment of residual infected burn wounds at late postburn stage. Methods Fifty-six patients with residual wounds at late postburn stage were enrolled in the study, and they were randomly divided into A（n = 28, experimental） and B （ n = 28, control ） groups. After treatment with immersion bath, the wounds in group A were treated with semi-exposure method. The wound were covered with suitable shape of biological dressings in suitable shape and rb-FGF2 spray twice a day after an immersion bath, and the dressing was changed every other day or every 2 days. To compare the treatment effect, the wounds in group B were only treated with a dressing of monolayer gauze wetted with povidone iodine. The clinical results, the bacteriological state findings, and the corresponding safety indices were determined 10 days after treatment. Results The wound healing rate, efficacy and the bacterial clearance rate in A group were 64.3% ,89.3% ,92.3% , respectively, and they were obviously higher than those in B group （32.1% , 67.9% , 72.0% , respectively, P 〈0.01 ）. No adverse side-effects were observed in either group. Conclusion Application of artificial dermis and bFGF after immersion bath is safe and effective for the elimination of residual wounds at late postburn stage, and it is also beneficial to control wound infection and promote the wound healing.
出处
《中华烧伤杂志》
CAS
CSCD
北大核心
2007年第1期40-42,共3页
Chinese Journal of Burns
关键词
烧伤
生物敷料
成纤维细胞生长因子2
细菌感染
浸浴
残余创面
Burns
Biological dressing
Fibroblast growth factor 2
Bacterial infection
Immersion bath
Residual wound
