摘要
目的：探索依那普利对慢性肾小球肾炎的疗效。方法：４４例慢性肾炎伴肾功能不全、持续性蛋白尿＞２．５ｇ／２４ｈ病人分成２组。治疗组２６例（男性１７例，女性９例；年龄３９±ｓ９ａ）采用依那普利１０～２０ｍｇ／ｄ，维持用药６ｍｏ。对照组１８例（男性１２例，女性６例；年龄３７±８ａ）给予降压药如硝苯地平等．２组病人均给予低蛋白（以优质蛋白为主）、低盐的限制性饮食．结果：依那普利组尿蛋白下降６５％±８％（Ｐ＜０．０１），优于对照组（Ｐ＜０．０１）；血肌酐和肾小球滤过率（ＧＦＲ）无明显变化（Ｐ＞０．０５）．，对照组尿蛋白亦减少（Ｐ＜０．０５），同时伴有血肌酐明显上升（Ｐ＜０．０１）和ＧＦＲ明显下降（Ｐ＜０．０１）。结论：依那普利有保护肾功能作用。
AIM : To probe the therapeutic effect of enalapril in treating chronic glomerulonephritis. METHODS: Forty-four patients with chronic glomerulonephritis complicated renal failure and stable proteinuria exceeding 2.5g/d were divided into two groups. The enalapril group of 26 patients(M 17,F9;age 39±s 9 a)received enalapril 10-20 mg/d for 6 mo .The control group of 18 patients(M12,F6;age 37± 8 a) were given antihypertensive drugs(eg,nifedipine) .All patients were prescribed low-protein(gave at first high quality protein ) and low-sodium diet.RESULTS:The proteinuria was decreased 65% ± 8%( P<0.01) ,superior to the control group(P<0.01) .The serum creatinine and glomerular filtration rate(GFR) were not much changed(P>0.05)in enalapril group,whereas the reduction in proteinuria(P<0.05) was associated to the serum creatinine increase(P<0.01) and the GFR decrease(P<0.01) in control group. CONCLUSION:Enalapril protects renal function.
出处
《新药与临床》
CSCD
北大核心
1996年第5期283-286,共4页
关键词
依那普利
肾炎
肾小球炎
药物疗法
enalapril
nephritis
proteinuria
chronic kidney failure
