摘要
目的:探讨大豆磷脂酰胆碱对血管性痴呆大鼠学习记忆能力的作用。方法:大鼠随机分为假手术组、模型组和磷脂酰胆碱组,采用双侧颈总动脉结扎法(2-VO法)建成血管性痴呆大鼠模型,分别通过Morris水迷宫系统和免疫荧光方法观察各组大鼠行为学和海马CA3区脑源性神经营养因子的变化。结果:长期服用磷脂酰胆碱可明显改善血管性痴呆模型大鼠的Morris水迷宫测试成绩,同时海马CA3区BDNF阳性细胞数目明显增多,光密度值减弱。结论:长期服用磷脂酰胆碱可对抗大鼠脑缺血后所致的学习记忆的损害。
Objection： To investigate the preventive effects of soybean phosphatidylcholine （ PC ）on spatial learning and memory deficits in rats with vascular dementia （VD）. Methods： The rats were divided into three groups at random： sham-operated group, model group and soybean PC group. Models of VD were established by permanent occlusion of the bilateral common carotid arteries （2-VO methods）, and subsequently all rats were tested in Morris water maze for 5 d. At the end of experiment, hippocampus of each rat was dissected and the brain derived neurotrophic factor （BDNF） was tested using immunohistochemical method. Results： In VD rats fed with soybean PC for long time, the maze testing score was significantly improved. Immunohistochemicai results showed that BDNF positive neurons in hippocampus were significantly increased and OD values reduced. Conclusion： Soybean phosphatidylcholin can prevent learning and memory impairment of cerebral blood flow in rats with VD.
出处
《营养学报》
CAS
CSCD
北大核心
2007年第1期20-22,共3页
Acta Nutrimenta Sinica
关键词
大豆磷脂酰胆碱
血管性痴呆
脑源性神经营养因子
学习记忆
soybean phosphatidylcholine
vascular dementia
brain derived neurotrophic factor
learning and memory
