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胃食管反流病发病中食管内脏感觉调控的研究进展 被引量:1

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摘要 胃食管反流病(gastroesophageal reflux disease,GERD)是指胃/十二指肠内容物反流到食管引起烧心、反酸等症状和(或)并发症的一种疾病。胃食管反流病是一种常见疾病,通过内镜检查存在食管黏膜损害者称为反流性食管炎(reflux esophagitis,RE);根据罗马Ⅲ标准,内镜下未见明显食管黏膜损伤者且符合以下任一项者为非糜烂性反流病(non-erosive reflux disease,NERD):(1)24h胃食管pH监测阳性者;(2)24h胃食管pH监测阴性但症状指数(symptom index)阳性者;(3)24h胃食管pH监测及症状指数均阴性;但质子泵抑制剂(PPI)诊断性治疗(PPI试验)有效者。NERD在GERD中占有较大比例。烧心是GERD的典型症状,发病率较高。群体调查研究显示,在北欧,烧心的发病率为38%,美国更高达42%。症状每月发作1次以上者超过40%,每周发作1次以上者达20%,每日均有症状者约7%。一项在日本进行的结合内镜检查的研究中,2760人参与了调查,结果显示GERD的发病率17,9%,NERD的发病率达10.9%(占GERD的60.6%)。另一项在中(国)、
作者 王琨 段丽萍
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第2期165-167,共3页 Chinese Journal of Internal Medicine
基金 教育部高等学校博士点基金(20050001142)
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参考文献38

  • 1Galmiche JP,Clouse RE,Bálint A,et al.Functional esophageal disorders.Gastroenterology,2006,130:1459-1465. 被引量:1
  • 2王琨,段丽萍,陈洪,夏志伟,林三仁.反流性食管炎与非糜烂性反流病食管酸暴露的特点比较[J].中华内科杂志,2005,40(1):5-8. 被引量:45
  • 3Martinez SD,Malagon IB,Garewai HS,et al.Non-erosive reflux disease (NERD)--acid reflux and symptom patterns.Aliment Pharmacol Ther,2003,17:537-547. 被引量:1
  • 4Delaney BC.Review article:prevalence and epidemiology of gastro-oesophagnal reflux disease.Aliment Pharmacol Ther,2004,20 Suppl 8:2-4. 被引量:1
  • 5Locke GR 3rd.Natural history of nonerosive reflux disease.Is all gastroesophageal reflux disease the same? What is the evidence?Gastroenterol Clin North Am,2002,31 (4 Suppl):S59-66. 被引量:1
  • 6Ikuyo M,Kyoichi A,Noriyuki A,et al.Prevalence of endoscopically negative and positive gastroesophageal reflux disease in the Japanese.Scand J Gastroenterol,2005,40:1005-1009. 被引量:1
  • 7Rosaida MS,Gob KL.Gastro-oesophageal reflux disease,reflux oesophagitis and non-erosive reflux disease in a multiracial Asian population:a prospective,endoscopy based study.Eur J Gastroenterol Hepatol,2004,16:495-501. 被引量:1
  • 8Hughes DA,Bodger K,Bytzer P,et al.Economic analysis of ondemand maintenance therapy with proton pump inhibitors in patients with non-erosive reflux disease.Pharmacoeconomics,2005,23:1031-1041. 被引量:1
  • 9Fass R.Sensory testing of the esophagus.J Clin Gastroenterol,2004,38:628-664. 被引量:1
  • 10Mertz H.Role of the brain and sensory pathways in gastrointestinal sensory disorders in humans.Gut,2002,51 Suppl Ⅰ:i29~i33. 被引量:1

二级参考文献27

  • 1An evidence-based appraisal of reflux disease management: the Genval Workshop Report. Gut, 1999,44 Suppl 2 : S1-S16. 被引量:1
  • 2Martinez SD, Malagon IB, Garewal HS, et al. Non-erosive reflux disease (NERD)-acid reflux and symptom pattern. Aliment Pharmacol Ther, 2003,17:537-545. 被引量:1
  • 3Fass R, Fennerty MB, Vakil N. Nonerosive reflux disease:current concept and dilemmas. Am J Gastroenterol, 2001,96:303-314. 被引量:1
  • 4Pace F, BoUani S, Molteni P, et al. Natural history of gastrooesophageal reflux disease without oesophagitis (NERD):a reappraisal 10 years on. Dig Liver Dis, 2004,36:111-115. 被引量:1
  • 5Peghini PL, Katz PO, Bracy NA, et all Nocturnal recovery of gastric acid secretion with twice-daily dosing of proton pump inhibitors. Am J Gastroenterol, 1998,93:763-767. 被引量:1
  • 6Lind T, Havelund T, Carlsson R, et al. Heartburn without esophagitis: efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol, 1997,32:974-979. 被引量:1
  • 7Fass R, Tougas G. Functional heartburn : the stimulus, the pain,and the brain. Gut, 2003,51:885-892. 被引量:1
  • 8Drossman DA. The functional gastrointestinal disorders and the Rome Ⅱ process. Gut,1999,45 Suppl 2 :Ⅱ 1-5. 被引量:1
  • 9Just RJ, Lelte LP, Castell DO. Changes in overnight fasting intragastric pH show poor correlation with duodenogastric bile reflux in normal subjects. Am J Gastroenterol, 1996,91:1567-1570. 被引量:1
  • 10Fass R. Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease. Am J Gastroenterol, 2003, 98(Suppl 3): S2-7. 被引量:1

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