摘要
目的:研究p27对增生性瘢痕成纤维细胞-胶原网收缩的影响差异,探讨p27在瘢痕形成中的作用。方法:取体外培养的人增生性瘢痕成纤维细胞(HTsFb),p27基因转染HTsFb,建立成纤维细胞-胶原网模型,观察p27基因转染对p27基因转染HTsFb-胶原网收缩的影响差异。结果:p27能抑制HTsFb-胶原网收缩。结论:p27可能通过抑制瘢痕收缩来抑制瘢痕形成。
Objective To study the effect of p27 gene transfection on contraction of human hypertrophic scar fibroblast-populated collagen lattice and to investigate the effect of p27 on scar forming. Methods In vitro cultured human hypertrophic scar fibroblasts （HTsFb）were cultured and p27 gene was transfected into HTsFb, and the effect of p27 gene on contraction of FPLC（fibroblast-populated collagen lattice） was measured. Results p27 gene transfection could inhibit the contraction of HTsFb-populated collagen lattice. Conclusion p27 might inhibit scar forming by inhibiting scar contracture.
出处
《中国美容医学》
CAS
2007年第1期19-21,共3页
Chinese Journal of Aesthetic Medicine
关键词
P27
成纤维细胞胶原网
瘢痕
p27
Fibroblast-populated collagen lattice
scar
