摘要
目的通过观察胆道肿瘤组织中β-连环素(β-catenin)与细胞周期素D1(cyclinD1)的表达,探讨它们和胆道肿瘤发生、预后的关系。方法应用免疫组织化学法研究33例胆囊癌,35例胆管癌中β-catenin与cyclinD1的表达特点,并结合临床资料进行统计学分析。结果10例正常的胆囊和胆管标本中β-catenin与cyclinD1均呈正常表达。而在33例胆囊癌组织中有16例(48.5%)β-catenin的异常表达和18例(54.5%)cyclinD1的过度表达;35例胆管癌组织中存在18例(51.4%)β-catenin的异常表达和16例(45.7%)cyclinD1的过度表达。在胆道恶性肿瘤中,β-catenin的表达异常和cyclinD1的过度表达与TNM分期和/或肿瘤的分化相关,而且β-catenin的异常表达与cyclinD1的过度表达相关(P<0.05)。结论在胆道恶性肿瘤组织中存在β-catenin的异常表达与cyclinD1的过度表达。β-catenin的异常表达与cyclinD1的过度表达之间的相关性提示,β-catenin/Wnt信号转导途径参与了胆道肿瘤的发生和发展。
[Objective] To investigate expression of β-catenin and cyclinD1 and its possible role in the tumors＇ development and progression. [Methods ] Expression of β-catenin and cyclinD 1 was immunohistochemically studied in gallbladder carcinoma （33 cases）, and cholangiocarcinoma （35 cases）, respectively. The results were analyzed with clinical-pathological data. [Results] Normal expression of β-catenin and cychnD1 was found in 10 cases of normal biliary control samples. Abnormal expression of β-catenin and cyclinD1 overexpression was detected in 48.5% （16/ 33） and 54.5% （18/33） in samples of gallbladder carcinoma respectively. Similarly, abnormal expression of β-catenin and cyclinD1 overexpression were also found in cholangiocarcinoma, 51.4% （18/35） and 45.7% （16/35） respectively. Abnormal expression of β-catenin and cyclinD1 overexpression were related to TNM stages and/or tumor differentiation in these biliary tumors. Furthermore, in both gallbladder carcinoma and cholangiocarcinoma, abnormal β- catenin expression was correlated with cyclinD 1 overexpression （P 〈0.05）. [ Conclusion] Abnormal expression of β- catenin and cyclinD1 overexpression exist in biliary tumors. Correlation between abnormal expression of β-catenin and cyclinD1 overexpression suggests that WNT/β-catenin signaling pathway plays a role in biliary tumors＇ development and progression.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第2期134-137,共4页
China Journal of Modern Medicine
基金
the Project Spinsored by the Scientific Research Foundation for the Returned Ouerseas Chinese, State Education Ministry.
