摘要
目的探讨神经干细胞(neural stem cells,NSCs)与血管内皮祖细胞(endothelial progenitor cells,EPCs)共移植治疗缺血性脑卒中应用的可能。方法检索并分析医学和生物医学数据库中与脑卒中干细胞治疗相关的NSCs与EPCs基础研究文献,并进行综述。结果NSCs与EPCs能向脑卒中损害区域趋化,局部微环境诱导两者启动神经新生与血管新生修复损伤,并且血管新生与神经新生能相互促进。结论NSCs和EPCs共移植为有效的解决缺血性卒中后神经元缺失与血管闭塞这两个病理损害提供了一种新的途径。
Objective To discuss the feasibility of treating the brain ischemic stroke by the co-transplantation of the neural stem cells（NSCs） and the endothelial progenitor cells（EPCs）. Methods The original biomedical articles concerned with the treatment of the brain ischemic therapy by the use of the NSCs and the EPCs were extensively reviewed as well as retrieved and analyzed. Results The review revealed that the NSCs and the EPCs could migrate to the injured area due to brain ischemic stroke, the environment of the local microcirculation could induce the neurogenesis and the vasculogenesis to repair the injury, and the neurogenesis and vasculogenesis could promote each other. Conclusion The co-transplantation of the NSCs and the EPCs can represent a new promising strategy for more effectively solving the two difficult problems of the neural cell loss and the vascular obstruction caused by the brain ischemic stroke.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2007年第2期204-208,共5页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
脑卒中
神经新生
血管新生
共移植
Brain isehemie stroke Neurogenesis Vaseulogenesis Co-transplantation
