摘要
缺血/再灌注(I/R)肾损伤是急性肾衰竭(ARF)的最常见病因。研究证实,内皮祖细胞(EPC)在血管新生和内皮再生,尤其在缺血性疾病治疗方面具有重要意义。最近对EPC在I/R损伤时所发挥的作用进行了探讨,取得了一定进展。本文综述I/R肾损伤后EPC的促血管新生作用。
Ischemia/reperfusion(I/R)renal injury is one of the most common reasons of acute renal failure(ARF).Several studies suggest that bone marrow derived endothelial progenitor cells(EPC)participate in regeneration of microvasculature of ischemic tissue.Recently,investigators have successfully transplanted EPC in facilitating angiogenesis after I/R renal injury.This review discusses the contribution of EPC in I/R renal injury.
出处
《世界临床药物》
CAS
2009年第2期72-75,共4页
World Clinical Drug
关键词
内皮祖细胞
缺血再灌注损伤
血管新生
endothelial progenitor cells
ischemia reperfusion injury
angiogenesis
