摘要
N-芳基-2-[(吡啶-4-基)羰基]氨基硫脲1a～1e用NaOH溶液环合,得到3-巯基-4-芳基-5-(吡啶-4-基)-1,2,4-三唑(2a～2e),经酯化,肼解,得S-{[4-芳基-5-(吡啶-4-基)]-1,2,4-三唑-3-基}巯乙酰肼(3a～3e),再与3-甲酰基色酮(4a～4d)反应,合成得到了一系列新化合物5a～5e,6a～6e,7a～7e,8a～8e.化合物的结构经元素分析,IR,1HNMR和MS谱确证.
A series of new compounds 5a-5e, 6a-6e, 7a-7e and 8a-8e were synthesized though condensation reaction of 3-formylchromones 4a-4d with S-{[4-aryl-5-（pyrid-4-yl）]-1,2,4-triazol-3-yl}- mercaptoacetylhydrazine （3a-3e） which were obtained by esterification and hydrazinolysis from 3-mercapto-4-aryl-5-（pyrid-4-yl）-1,2,4-triazoles （2a-2e） cyclized from N-aryl-2-[（pyrid-4-yl）-carbonyl] thiosemicarbazide （1a-1e） in NaOH solution. Their structures were established by elemental analysis, IR, ^1H NMR and MS spectra.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2007年第2期255-260,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.29962002
20462006)资助项目.
