摘要
血管紧张素转换酶2(ACE2)和Mas受体的发现使人们对肾素-血管紧张素(RAS)有了更全面的认识。ACE2可水解血管紧张素Ⅰ和血管紧张素Ⅱ直接或间接生成血管紧张素1-7(Ang1-7),并与高血压的形成密切相关。Ang1-7主要通过Mas受体引起血管舒张、抑制细胞增殖。ACE2-Ang1-7-Mas轴的发现为RAS的研究、高血压等心血管疾病的防治和新药开发提供了新的思路和方向。
The recent identification of angiotensin-converting enzyme 2 （ACE2） and Mas receptor opened new recognition of renin-angiotensin system （RAS）. ACE2, a homologue of angiotensin-converring enzyme （ACE） generates angiotensin 1-7 directly through cleaving angiotensin Ⅱ, or indirectly through angiotensin Ⅰin the body. Ang 1-7 exhibits vasodilatory and antiproliferative effects, and these effects were mainly mediated by Mas receptor. So ACE2-angiotensinl-7- Mas axis was considered a negative regulation in renin angiotensin system （RAS）, and its significance has been implicated into hypertension and other cardiovascular diseases. The identification of the axis opens a new potential venue for further study and understanding of RAS.
出处
《生理科学进展》
CAS
CSCD
北大核心
2007年第1期43-48,共6页
Progress in Physiological Sciences
