摘要
目的通过影像检查方法,随访观察阿苯达唑脂质体口服液治疗肺包虫病的影像表现,对药物治疗肺包虫病的疗效作出评价。方法 16例肺包虫病患者,服用阿苯达唑脂质体口服液10 mg/kg,2次/d,连续服用3～10个月。服药前、后定期检查胸部 X 线片、CT 及 MRI,观察病变大小及形态学变化及有关实验室检查。通过治愈、有效、部分有效、无效来评价药物疗效。结果治愈5例、有效6例、部分有效4例、无效1例。治疗后影像表现为:包虫囊肿变性、囊液吸收呈空洞7例;病灶体积缩小6例;病灶消失、数目减少2例;囊肿实变、病灶密度不均匀增高6例;囊肿破裂、皱缩、内囊塌陷3例;病灶出现钙化6例。结论阿苯达唑脂质体口服液治疗肺包虫病有肯定疗效,影像检查有助于了解肺包虫囊肿的形态特征和病理演变过程,对肺包虫病药物治疗其疗效观察有重要价值。
Objective To evaluate the image features of lung echinococcosis under chemotherapy with liposome-entrapped albendazole. Methods Sixteen patients with lung echinococcosis who took orally liposome-entrapped albendazole （10 mg/kg, Bid, 3 to 10 months） were examined by X-ray film, CT or MR before therapy and followed-up by those imaging studies after therapy. The morphological changes of the lesions as reflected on imaging findings were reviewed, with correlation of the clinic check-ups and laboratory tests, to judge effectiveness of the treatment. Results Five cases were completely cured. The treatment was effective in 6 cases, partially effective in 4 and invalid in 1 case. The imaging findings included： cavity formation in 7 cases due to hydatid cyst degeneration and absorption of cyst liquid; reduction in lesion size in 6 cases; disappearance of lesion or decrease in lesion numbers in 2 cases; increase in lesion density and blurring of cyst wall in 6 cases duo to cyst consolidation; rapture, shrinkage, collapse of cyst inner membrane in 3 cases; calcification of the cyst wall or contents in 6 cases. Conclusions It is shown that liposome-entrapped albendazole chemotherapy has curative effect for lung echinococcosis. Imaging examinations are effective for monitoring the evolution of the disease by depicting the morphologic-pathologic changes of the lesions.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2007年第1期40-42,共3页
Chinese Journal of Radiology
