摘要
目的研究慢性乙型肝炎患者外周血单个核细胞(PBMC)内乙型肝炎病毒脱氧核糖核酸(HBV-DNA)与肝组织损伤程度的相关性。方法采用聚合酶链反应方法测定119例慢性乙型肝炎患者PBMC内HBV-DNA定量,并对肝组织进行病理学诊断。结果119例乙型肝炎患者PBMC内HBV-DNA检出率为71.4%,轻度、中度、重度慢性乙型肝炎患者PBMC内HBV-DNA阳性率分别为58.1%、69.4%、84.6%;慢性乙型肝炎患者PBMC内HBV-DNA检出率与肝组织损伤程度呈正相关(rs=0.912,P<0.05)。结论PBMC中HBV-DNA阳性率随肝损害加重而升高。
Objective To study the relation of hepatitis B virus DNA （HBV-DNA） in peripheral blood mononuclear cells（PBMC） and the damage of liver tissue for the patients with chronic hepatitis B. Methods HBV-DNA in PMBC was determined by polymerase chain reaction and the damage of the liver tissue was detected by pathological diagnosis. Results HBV-DNA positive rate in PBMC was 71.4% and the positive rates of mild,medium, severe chronic hepatitis B were 58.1 % ,69.4 % ,84.6%, respectively. HBV-DNA positive rate in PBMC was positively related with the damage level of the liver tissue（ rs =0. 912, P 〈0.05）. Conclusion HBV-DNA in PMBC increases along with the damage of liver tissue.
出处
《临床荟萃》
CAS
北大核心
2007年第2期87-88,共2页
Clinical Focus
