摘要
目的制备克拉霉素(CLM)纳米乳,并对药物释放机制进行初步研究。方法以乙基纤维素(EC)为阻滞材料,将CLM制成缓释纳米乳,考察EC的种类及用量、油水相比例、乳化剂用量和制备工艺等对其体外释放度的影响。结果CLM纳米乳的体外释药符合H iguchi规律,释药速率主要受EC的种类及用量、乳化剂用量和制备工艺等因素的影响。结论CLM纳米乳体外释药符合缓释制剂要求。
Objective To optimize the preparation procedure of water-in-oil nanoemulsion of clarithromycin and investigate its in vitro dissolution behavior.Methods Clarithromycin nanoemulsion was prepared by mixing clarithromycin with the ethylcellulose.Factors related to clarithromycin in vitro release characteristics were evaluated,which included type and quantity of ethylcellulose and emulsifier,ratio of water to oil.Results The type and quantity of ethylcellulose,the amount of emulsifier,preparation method were closely related to the in vitro dissolution of clarithromycin.The dissolution data of the nanoemulsion were best described by Higuchi model.Conclusion The profile of clarithromycin nanoemulsion indicates that the nanoemulsion is an ideal sustained-release formulation.
出处
《广东药学院学报》
CAS
2006年第6期579-582,共4页
Academic Journal of Guangdong College of Pharmacy
基金
广州市科技攻关重点项目(2003E2-E1061)
关键词
克拉霉素
纳米乳
乙基纤维素
释放度
clarithromycin
nanoemulsion
ethylcellulose
in vitro dissolution
