摘要
选择素是黏附分子的一个家族,由P-选择索、L-选择素和E-选择素组成。这3种黏附分子均参与了脑缺血再灌注损伤的炎症过程。P-选择素在激活的血小板和内皮细胞表达,而E-选择素仅在血管内皮细胞表达,两者共同介导白细胞、血小板与内皮细胞的黏附。L-选择素主要在白细胞表达,介导白细胞在微血管内皮细胞上的滚动接触。
Selectins are a family of adhesion molecules, including P-, L-, E-selectins. The three adhesion molecules all participate in the inflammatory processes of ischemia-reperfusion injury of brain. P-selectin is expressed on activated platelets as well as on endothelial cells. E-selectin is only expressed on endothelial cells. P- and E-selectm mediate the adhesion of the leukocytes, platelets and endothelial cells. L-selectin is mainly expressed on leukocytes and mediates leukocytes rolling contact with microvascular endothelial cells.
出处
《国际脑血管病杂志》
2006年第11期858-861,共4页
International Journal of Cerebrovascular Diseases
关键词
选择素
脑缺血
再灌注损伤
selectin
cerebral ischemia
reperfusion injury
