摘要
目的探讨血小板膜表面P-选择素的表达在病毒性脑炎(病脑)发病中的作用及其与重症病毒性脑炎脑软化灶形成的关系。方法采用流式细胞技术测定44例病脑患儿(轻症组20例,重症组24例)和20例健康对照儿童外周血P-选择素阳性表达率,头颅CT测量脑软化灶的大小。结果重症组病程<5d时,P-选择素表达率明显高于对照组及轻症组(P<0.01,P<0.05).病程满2周时已明显下降(P<0.01).但仍高于对照组(P<0.01);病程<5d时P-选择素表达率与同期脑软化灶的大小呈显著正相关(r=0.35P<0.05)。结论重症病脑患儿有明显血小板活化,活化的血小板可能参与脑软化形成这一病理损伤过程。
Objective To study the clinical significance of P-selection expression in children with viral encephalitis and the correlation between this expression and the cerehral infarction with critical viral encephalitis.Methods Flow cytometric was employed to detect the expression of P -selection on the ,surface of platelet membrane in 44 children with viral encephalitis（20 light patients and 24 critical patients） and 20 healthy control children. The area of the cerebral infarction was determined by computed tomographic scan in 20 patients with critical viral encephalitis. The correlation between the two variables was analyzed. Results The expressions of P-selection on the surface of platelet membrane on less than 5 days and on 2 weeks after the onset of viral encephalitis were .significantly higher in critical patients than those in normal eontrol children and light patients（ P〈 0.01 ）respectively. A significant correlation existed between the area of the cerebral infarction and the expression of P- selection（ r=0.35 P〈 0.05）. Conclusion Platelets in patients with critical viral encephalitis are markedly activated, which are then possibly concerned with the cerebral infarction formation.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第10期1015-1016,共2页
Journal of Applied Clinical Pediatrics
关键词
脑炎
病毒性
P-选择素
流式细胞术
脑软化
viral encephalitis
P-selection
flow cytometric
cerebral infarction
