摘要
回顾性分析57例胸段食管癌患者根治术后预防性放射治疗的肺功能变化,采用自身配对方法检测治疗前后肺通气、线速容量曲线、弥散功能和残气容积项目。结果:对术后放疗前肺功能检查显示轻、中、重肺功能不全或限制性通气功能障碍者,仍可耐受5周50Gy/25次的预防性放疗剂量,但该剂量对弥散功能下降是有影响的。弥散功能DLCO/SB(58.20±18.30、44.67±17.42,P=0.001)、DLCO/VA(77.39±18.00、66.39±20.89,P=0.007)差异有统计学意义。初步研究结果提示,弥散功能DLCO/SB、DLCO/VA指标在观察食管癌根治术后预防性放疗后肺功能变化可能是最敏感的指标。
A retrospective analysis of 57 patients with curative resection of thoracic esophageal cancer who did pulmonary function tests before and after prophylactic radiotherapy. T fields irradiation technique. Dr 50 Gy/25 F, self matched-pairs. All the postoperative patients no matter the pulmonary function test showed mild medium or severe pulmonary dysfunction or restrictive ventilation functional disturbance accepted the Dr 50 Gy/25 F prophylactic radiotherapy. The pulmonary diffusion function DLco/SB （58. 20 ± 18. 30, 44. 67 ± 17.42, P = 0. 001）, DLco/VA （77. 395±18.00, 66. 39± 20. 89, P = 0. 007） were significantly decreased after radiotherapy. Diffusion function DLco/SB and DLco/VA is one of may sensitive index to evaluate the pulmonary function of pre-and-post prophylactic radiotherapy after curative resection of esophageal carcinoma.
出处
《中华肿瘤防治杂志》
CAS
2006年第21期1662-1663,共2页
Chinese Journal of Cancer Prevention and Treatment
