摘要
目的探讨嗜麦芽寡养单胞菌(SMA)下呼吸道感染和对抗菌药物的耐药状况。方法回顾性分析79例嗜麦芽寡养单胞菌下呼吸道感染患者的相关临床资料,并采用ATBPSE 5流体双浓渡法试剂盒进行药敏试验。结果全部患者均有基础疾病,经验性应用广谱抗菌药物达100%,>60岁患者占74.68%、接受气管插管或气管切开等各种侵入性操作51.90%、机体免疫功能受损患者62.03%,是引起嗜麦芽寡养单胞菌下呼吸道感染的高危因素;对抗菌药物呈广泛耐药,仅对替卡西林/克拉维酸和复方新诺明保持较高的抗菌活性。结论降低嗜麦芽寡养单胞菌医院感染的发生因素,临床治疗首选药物为替卡西林/克拉维酸和复方新诺明,联合应用氟喹诺酮和头孢他啶可以提高治愈率。
OBJECTIVE To study the lower respiratory tract infection caused by Stenotrophomonas maltophilia and the resistance situation. METHODS The clinical data of 79 cases of lower respiratory tract infection caused by S. maltophilia were analyzed and the susceptibility test was made using ATBPSE5 kits. RESULTS All patients had clinical symptoms, and the rate of empirical using of broad-spectrum antibiotics reached to 100%. In all these patients,74. 68% were older than 60, and 51.90% received invasive operation such as trachea intubation or incision, and the immmunosystem function of 62.03% was compromised. All these were high risk factors resulting in the lower respiratory S. maltophilia infection. All cases showed resistance to most broad-spectrum antibiotics except ticarcillin/clavulanic acid and sulfamethoxazole/trimethoprim（Cotrimoxazole）. The latter two antibiotics still showed high sensitivity to the pathogen. CONCLUSIONS It is necessary to avoid the risk factors causing nosocomial S. maltophilia infection. Ticarcillin/clavulanic acid and Cotrimoxazole are the first choice for clinical treatment. Using fluoroquinolone and ceftazidime simultaneously can improve the curing rate.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第12期1419-1421,共3页
Chinese Journal of Nosocomiology
关键词
嗜麦芽寡养单胞菌
下呼吸道感染
抗菌药物
药敏率
Stenotrophomonas maltophilia
Lower respiratory tract infection
Antibiotics
Susceptibility rate
