摘要
目的:研究胃腹气痛胶囊对肠运动功能的影响。方法:通过其对正常小鼠和新斯的明化小鼠肠推进、对麻醉豚鼠肠运动及离体豚鼠回肠运动影响的体内体外研究,评价胃腹气痛胶囊对肠运动功能的影响。结果:胃腹气痛胶囊对正常小鼠肠推进运动影响很小,但可显著抑制新斯的明化小鼠肠推进运动亢进。低剂量组和中剂量胃腹气痛胶囊可显著促进麻醉豚鼠回肠运动,而高剂量组则显著抑制其运动。胃腹气痛胶囊对离体豚鼠回肠平滑肌的自发收缩活动呈先兴奋后抑制的作用特点,并可显著抑制乙酰胆碱、组织胺和氯化钡引起的豚鼠回肠痉挛性收缩。结论:胃腹气痛胶囊对肠运动功能表现为低剂量兴奋高剂量抑制的双向调节作用。该药在临床治疗腹胁疼痛的作用机制可能与其抗M受体和H1受体效应,从而解除胃肠道平滑肌痉挛有关。
Objective： To study the effect of Weifuqitong capsule on intestinal movement to provide experimental evidence for it usage in clinical practice. Methods ： The effects of Weffuqitong capsule on instestinal propulsion of normal mice or mice injected by s. c neostigmine, on ileal peristalsis of anesthetize gn.inea pig and movement of isolated ileum were detected. Results： Weffuqitong capsule showed significant inhibition no excited instestinal propulsion induced by neostigmine, but had on effect on normal instestinal propulsion. Low and middle dose of Weifuqitong capsule promoted ileal peristalsis of anesthetized guinea pig, yet high dose of weifu qitong capsule inhibited it. Weifuqitong capsule first excited then inhibited movement of isolated ileum, and prevented its spastic contraction induced by acetylcholine, histamine and barium chloride. Conclusion： Low dose of Weifuqitong capsule excited but high dose inhibited intestinal movement. Anti - cholinergic and anti - histamergic effects to remove gastrointestinal spasmus maybe involved in the mechanisms of its relieving abdominal pain.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第6期63-65,共3页
Pharmacology and Clinics of Chinese Materia Medica
关键词
肠运动
胃腹气痛胶囊
propulsive of intestine
Weifuqitong capsule（胃腹气痛胶囊）
