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熟地 苍术及两者不同配伍比例对大鼠残余肾功能的影响及其相使作用的研究 被引量:6

The Study of the Affection of Shu Di Cang Zhu and Different Compatibility Proportion of Them to White rat's Remnant Renal Function and the Mutual Assistance Effect of Them
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摘要 目的:观察熟地、苍术及二者不同配伍比例保护大鼠残余肾的作用,探讨熟地、苍术的相使作用,并寻找熟地、苍术的最佳配伍比例。方法:采用大鼠5/6肾切除动物模型,分为单味熟地组、熟地+苍术(1∶1)组、熟地+苍术(2∶1)组、熟地+苍术(1∶2)组、单味苍术组、模型空白对照组、正常对照组,观察各组大鼠治疗后血红蛋白(HGb)、肾功能(Scr)、转化生长因子β1的表达。结果:单味熟地组、熟地+苍术(1∶1)组、熟地+苍术(2∶1)组与模型组相比有较大差异(P<0.05)。组间比较:熟地伍苍术(1∶1)组与单味熟地、熟地伍苍术(1∶2)、熟地伍苍术(2∶1)、单味苍术组间有差异(P<0.05)。结论:熟地与苍术配伍应用具有良好的中药相使作用,且以1∶1的配伍比例应用,疗效最佳。 Objective : Observe the function of Shu Di,Cang Zhu and different compatibility proportion of them to protect white rat's remnant renal function,explore the mutual assistance effect of Shu Di and Cang Zhu; seek the best compatibility proportion of them. Methods :Use white rats of 5/6 kidney cut as the experiment animal model, divide them into the following groups: Shu Di only,Shu Di and Cang Zhu ( 1:1 ) ,Shu Di and Cang Zhu(2:1 ) ,Shu Di and Cang Zhu( 1: 2) ,Cang Zhu only,blank control of model,control group of normal. Observe the hemoglobin (HGb), renal function (Scr) and the expression of transforming growth factor β1of the rats after the treatment. Results :There' re obvious differences between group of Shu Di only,Shu Di and Cang Zhu ( 1 : 1 ) ,Shu Di and Cang Zhu(2:1 ) ,and group of model ( P 〈 0.05 ). Comparision among different groups : there' re differences between groups of Shu Di and Cang Zhu ( 1:1 ) ,Shu Di only,Shu Di and Cang Zhu( 1; 2) ,Shu Di and Cang Zhu(2:1 ) and group of Cang Zhu only( P 〈 0.05). Conclusion :Shu Di and Cang Zhu used compatibility have good mutual assistance effect and the compatibility proportion of 1:1 has the best curative effect.
出处 《中医药学刊》 2006年第12期2230-2232,共3页 Study Journal of Traditional Chinese Medicine
基金 山东省教育厅资助课题(J00K55)
关键词 熟地 苍术 配伍 TGF-Β1 Shu Di Cang Zhu compatibility transforming growth factor β1
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