摘要
目的:观察银杏叶片对慢性阻塞性肺疾病患者肺功能及血清中高迁移率族蛋白B1和肿瘤坏死因子α的影响。方法:将郫县中医院2005/2006收治的慢性阻塞性肺疾病患者122例按就诊顺序分为2组:①对照组60例,给予去除病因、抗感染、康复锻炼等常规治疗。②治疗组62例,在对照组基础上予银杏叶片80mg口服,3次/d。3个月为整个疗程。观察两组患者治疗前后肺功能变化、血液流变学变化及血清中高迁移率族蛋白B1和肿瘤坏死因子α表达变化。另选20例健康人为正常组。结果:142例受试者均进入结果分析。①肿瘤坏死因子α的质量浓度:治疗后治疗组显著低于对照组犤(6.12±0.56),(10.42±0.99)ng/L,P<0.01犦,但仍高于正常组犤(3.12±0.54)ng/L,P<0.01犦。②高迁移率族蛋白B1表达:慢性阻塞性肺疾病患者较正常组高,治疗组治疗后低于同期对照组。③肺功能:治疗后治疗组第1秒用力呼气量及第1秒用力呼气容积占肺活量的百分率高于同期对照组犤(1.73±0.13),(1.49±0.16)L;(63.5±4.3)%,(56.9±4.8)%;P均<0.05犦,平均肺动脉也低于对照组犤(4.01±0.51),(4.63±0.57)kPa,P<0.05犦。④血液流变学指标:治疗后治疗组全血黏度、血浆黏度、红细胞聚集指数及红细胞压积显著降低,低于同期对照组(P<0.05)。结论:慢性阻塞性肺疾病患者血清中高迁移率族蛋白B1和肿瘤坏死因子α水平显著上升,银杏叶片可改善患者肺通气功能,改善血液流变学状况并降低高迁移率族蛋白B1和肿瘤坏死因子α水平。
AIM：To observe the effect of ginkgo leaf on the pulmonary function of patient with chronic obstructive pulmonary disease （COPD） and the expression of high mobility group protein B1 （HMGB1） and tumor necrosis factor α （TNF-α） in serum. METHODS：122 COPD patients admitted to the Pixian County Hospital of Chinese Medicine between 2005 and 2006 were divided into 2 groups according to their visiting sequence： ①control group （n=60）, which received normal treatment including eliminating the cause of disease, antiinfection and rehabilitation exercise; ②treatment group （n=62）, which orally took 80 mg ginkgo leaf tablet, three times daily besides the normal treatment for the control group. Three months served as one course. The changes in pulmonary function, hemorheology and the level of HMGB1 and TNF-α in serum were detected before and after treatment. Another 20 healthy people were selected as normal group. RESULTS： All 142 subjects were involved in the result analysis.①Mass concentration of TNF-α： The mass concentration of the treatment group after treatment was significantly lower than the control group [（6.12±0.56）, （10.42±0.99） ng/L, P 〈 0.01], but higher than the normal group [（3.12 ±0.54） ng/L, P 〈 0.01]. ②Expressions of HGMBI： The expressions of COPD patients were higher than the normal group, and the treatment group after treatment was lower than the control group at the same stage.③ Pulmonary function： FEV1 and FEV1% of the treatment group after treatment were higher than the control group at the same stage [（1.73±0.13）, （1.49±0.16） L; （63.5±4.3）%, （56.9±4.8）%; all P 〈 0.05], and the level of mean pulmonary arterial pressure was lower than that in the control group [（4.01±0.51）, （4.63±0.57） kPa, P 〈 0.05]. ④Hemorheological indexes： The whole blood viscosity, plasma viscosity,Erythrocyte aggregation index and hematocrit of the treatment group after treatment were decreased significantly, which were lower than
出处
《中国临床康复》
CSCD
北大核心
2006年第47期79-81,共3页
Chinese Journal of Clinical Rehabilitation
