摘要
目的:研究几种静脉输液在输液器中混合时发生沉淀的原因,测定其pH值和含量变化。方法:采用紫外分光光度法测定配伍前后药物含量变化;用酸度计测定pH值变化。结果:注射用炎琥宁与维生素B6注射液混合时pH值下降,产生沉淀,含量下降;注射用阿洛西林钠与奥硝唑注射液、硫普乐宁冻干粉针溶媒使用不当配制的输液等酸性药物混合时,pH值下降产生沉淀。结论:炎琥宁与维生素B6注射液、阿洛西林钠与臭硝唑氯化钠注射液等酸性注射剂不可配伍使用。
Objective：To assess the compatibility of several infusion solutions when they were mixed. Methods： A few infusion solutions were competed and then the stability of the drug contents were monitored by ultraviolet spectrophotometry. The changes of pH values were measured by a pH meter. Results：The non-compatibility of Yanhuning for injection with vitamin B6 for injection was found, manifesting the reductions of pH value and Yanhuning concentration as well as the occurrence of precipitation. The combination of azlocillin sodium for injection with omidazole for injection and tiopronin powders for injection led to the unwanted precipitation due to pH values down. Conclusion ：The non-compatibility of Yanhuning with vit B6 for injection and azlocillin with omidazole for injection were verified.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第23期2052-2054,共3页
Chinese Journal of New Drugs
关键词
注射用炎琥宁
维生素B6注射液
注射用阿洛西林钠
奥硝唑注射液
注射用硫普罗宁
配伍稳定性
Yanhuning for injection
viatamin B6 injection
azlocillin sodium for injection
omidazole and sodium chloride injection
tiopronin for injection
compatible stability
