摘要
目的探讨喉鳞状细胞癌Paxillin蛋白表达的临床意义。方法运用免疫组化S-P法检测石蜡包埋喉鳞癌标本74例,以及癌旁正常组织70例,癌旁轻度、中度、重度不典型增生黏膜上皮组织65、697、2例,分析比较Paxillin蛋白表达水平与患者各类临床资料的相关性及其临床意义。结果喉鳞癌组织Paxillin阳性率明显高于正常组织标本(P<0.05),不同分化程度癌组织的Paxillin阳性率也存在显著性差异,低分化者阳性率明显高于高和中分化组(P=0.001),伴有颈部淋巴结转移者阳性率明显高于无转移者(P=0.000),而且临床Ⅳ期病例阳性率又明显高于其他各期患者(P=0.000)。结论Paxillin的阳性表达水平与喉鳞状细胞癌的分化程度、颈淋巴结转移、临床分期有明显相关性,对其病理过程具有一定影响。
Objective To investigate the clinical implications of paxillin expressing in laryngeal squamous cell carcinoma （LSCC）. Methods Included in this study were 74 samples of LSCC, 70 samples of paraeanceous healthy tissue, and 65, 69 and 72 eases of paracanceous dysplastic tissue samples at mild, moderate and severe degrees respectively. The expression of paxillin in them was detected by means of immunohistoehemieal S-P procedures. Then, comparative analysis was made to explore the association of paxillin expressing With various kinds of clinical data and to see its clinical implications of paxillin. Results The positive expressing rate of paxillin in LSCC was significantly higher than that in healthy tissue samples （P〈0.05）. Furthermore, such a difference was also seen among the samples with differently differentiating levels, seen with very higher positive expressing rate of paxillin in poorly differentiated cancerous tissues （P 〈 0. 001）, very higher positive rate among the eases with neck lymph node metastasis （P 〈 0. 000）, and vexy higher positive rate among the eas- es at IV clinical staging （P 〈 0. 000）. Conclusions There are significant associations of paxillin expressing with differentiating levels, neck metastasis and clinical staging of LSCC, and the activity of paxiiin expression holds significant implications in the developing course of this tumor.
出处
《中国中西医结合耳鼻咽喉科杂志》
2006年第6期351-353,共3页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
基金
广东省科技厅基金资助项目(2002C30403
2005B10401048)
