摘要
目的探讨血浆超敏C反应蛋白(hs-CRP)水平、左室射血分数(LVEF)与冠脉粥样斑块特征的关系。方法对7例稳定性心绞痛(SA)、29例不稳定性心绞痛(UA)患者进行临床研究。所有研究对象均行冠状动脉造影(CAG)、血管内超声(IVUS)检查,均测定血浆hs-CRP水平。对其中的7例SA患者、27例UA患者行左室造影(LVA)检查测定LVEF水平。观察hs-CRP、LVEF水平与斑块特征的关系。结果不稳定型斑块组血浆hs-CRP水平非常显著地高于稳定型斑块组(P<0.01),冠脉中重度狭窄组与轻度狭窄组类似(P>0.05)。冠脉中重度狭窄组LVEF水平非常显著地低于轻度狭窄组(P<0.01),不稳定型斑块组与稳定型斑块组类似(P>0.05)。结论hs-CRP水平有望成为反映粥样斑块不稳定程度的敏感指标,但不能反映冠脉病变狭窄程度。LVEF水平可反映冠脉病变狭窄程度。但在SA、UA患者中,LVEF水平不能反映斑块稳定程度。
[Objective]To respectively elucidale the relation between the circulating level of high-sensitivity C-reactive protein（hs-CRP）, the level of left ventrieular ejection fraction（LVEF） and features of atherosclerotic plaques in coronary artery. [Methods]A clinical research was accomplished in 7 stable angina （SA） patients and 29 unstable angina （UA） patients. All were examined by CAG and IVUS. Concentrations of hs CRP were measured in all. Seven patients with SA and 27 patients with UA underwent LVA to measure LVEF. [Results]The concentration of hs CRP was significantly higher in unstable plaque group compared with stable plaque group （ P 〈0.01 ）, while there was no difference between slight stenosis group and medium-severe stenosis group（ P 〉0.05）. The level of LVEF was significantly lower in medium severe stenosis group compared with slight stenosls group （ P 〈0.01）, but there was no difference between stable plaque group and unstable plaque group（ P〉0.05）. [Conclusion]The hs-CRP level might reflect the unstable activity of the plaques, but has no relation with the stenosis of coronary artery segment. While the LVEF level might reflect the stenosis of coronary artery segment, but in patients with SA and patients with UA, the LVEF level has no obvious relation with the vulnerability of atheroselerotic plaques.
出处
《医学临床研究》
CAS
2006年第11期1751-1754,共4页
Journal of Clinical Research
关键词
冠状动脉硬化
C反应蚤白质
coronary arteriosclerosis
C-reactive protein
