摘要
目的从露水草总甾酮中分离β蜕皮甾酮并对其进行结构修饰。方法采用硅胶柱色谱分离β蜕皮甾酮,并以其为原料通过化学合成的各种手段合成结构类似物,利用光谱分析方法对所得化合物进行结构确证。结果与结论从露水草总甾酮中分离了β蜕皮甾酮(20 hydroxyecdysone)及另一含量较大的筋骨草甾酮C(ajugasterone C)。以分离的β蜕皮甾酮为原料化学合成了5种植物甾酮。分别是2,3,20,22双异丙叉基β蜕皮甾酮(20 hydroxyecdysone 2,3,20,22 diacetonideⅠ)、20,22异丙叉基β蜕皮甾酮(20 hydroxyecdysone 20,22 acetonideⅡ)、2,3,20,22双异丙叉基25乙酰基β蜕皮甾酮(viticosterone E 2,3,20,22 diacetonideⅢ)、2,3异丙叉基β蜕皮甾酮(20 hy-droxyecdysone 2,3 acetonideⅣ)、2,3异丙叉基22羰基β蜕皮甾酮(22 oxo 20 hydroxyecdysone2,3 acetonideⅤ)。
Objective To isolate 20-hydroxyecdysone from the total phytoecdysteroids in Cyanotis arachnoidea C. B. Clarke and try its structure modification. Methods 20-hydroxyecdysone was isolated by chromatography on silica gel column and some analogues were obtained from 20-hydroxyecdysone via chemical methods. The products were identified on the basis of physicochemical properties and spectral analysis. Results and conclusions Ajugasterone C and 20-hydroxyecdysone were isolated from total phytoecdysteroids and five phytoecdysteroids were synthesized as 20-hydroxyecdysone 2, 3, 20, 22-diacetonide; 20-hydroxyecdysone 20, 22-acetonide; Viticosterone E 2, 3, 20, 22-diacetonide; 20-hydroxyecdysone 2, 3-acetonide; 22- oxo-20-hydroxyecdysone 2, 3-acetonide respectively.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2006年第11期702-705,共4页
Journal of Shenyang Pharmaceutical University
关键词
β-蜕皮甾酮
分离
结构修饰
20-hydroxyecdysone
isolation
structural modification
