摘要
目的探讨高血压脑出血血肿局部血小板激活因子(PAF)、一氧化氮(NO)、内皮素(ET)的水平变化及临床意义。方法采用放射免疫法和酶联免疫吸附法动态监测68例轻、中、重度高血压脑出血血肿灶冲洗液中PAF、NO、ET的水平变化。结果高血压脑出血发病4 h血肿冲洗液中已检测出PAF,轻型组患者PAF于24 h达高峰,之后逐渐降低,中、重度组患者PAF于24-48 h达高峰。NO、ET出现于脑出血后12 h,并随病情变化呈现不同变化趋势。结论脑出血后血肿灶PAF、NO、ET水平的变化与疾病的转归密切相关。
Objective To investigate the dynamic change of PAF, NO, ET in hematomal fluid after hypertensive cerebral hemorrhage and to explore the clinical significance. Methods From March 2003 to January 2006 68 patients accepted micro - injury operation in Emergency Department were studied, and the change of PAF, NO, ET in hematomal fluid was observed continuously. Results PAF was found at 4h and reached a peak at 24 h after the hemorrhage, then decreased in the mild damaged group, but PAF reached a peak at 24 -48 h after cerebral hemorrhage in the moderate and severe damaged group. NO, ET was found at 12 h after the hemorrhage and reached peaks at different times. Conclusions PAF, NO, ET involved in the pathological process of cerebral hemorrhage and might have close relationship with the prognosis of hypertensive cerebral hemorrhage.
出处
《中国急救医学》
CAS
CSCD
北大核心
2006年第11期812-814,共3页
Chinese Journal of Critical Care Medicine
关键词
脑出血
血小板激活因子
一氧化氮
内皮素
Cerebral hemorrhage
Platelet activating factor（PAF）
Nitrous oxide（NO）
Endotoxin （ET）
