期刊文献+

NEPH1与蛋白尿机制的新进展 被引量:1

原文传递
导出
摘要 NEPH1是一种新发现的在足细胞裂孔隔膜上表达的跨膜蛋白,具有组成滤过屏障和信号转导等功能。它与裂孔隔膜上的其他的组成蛋白有着密切的结构和功能上的联系,在裂孔隔膜的结构组织、功能调节等方面有重要作用。进一步研究NEPH1与蛋白尿形成的关系,对原发性肾小球疾病和遗传性肾病的诊治有重要意义。
作者 胡廷海 张玲
出处 《国际泌尿系统杂志》 2006年第6期858-861,共4页 International Journal of Urology and Nephrology
  • 相关文献

参考文献17

  • 1Kawachi H,Koike H,Shimizu F.Molecular structure and function of the slit diaphragm:expression of nephrin in proteinuric states and in developing glomeruli.Nephrol Dial Transplant,2002,17(suppl9):20-22. 被引量:1
  • 2Donoviel DB,Freed DD,et al.Proteinuria and perinatal lethality in mice lacking NEPH1,a novel protein with homology to NEPHRIN.Mol Cell Biol,2001,21(14):4829-36. 被引量:1
  • 3Sellin L,Huber TB,et al.NEPH1 defines a novel family of podocin interacting proteins.FASEB J,2003,17(1):115-7. 被引量:1
  • 4Barletta GM,Kovari IA,Verma RK,et al.Nephrin and Neph1 colocalize at the podocyte foot process intercellular junction and form cis hetero-oligomers.J Biol Chem,2003,278(21):19266-71. 被引量:1
  • 5Gerke P,Huber TB,Sellin L,et al.Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1.J Am Soc Nephrol,2003,14(4):918-26. 被引量:1
  • 6Benzing,Thomas,et al.Signaling at the Slit Diaphragm.Journal of the American Society of Nephrology.June,2004,15(6):1382-1391. 被引量:1
  • 7Kestila M,Lenkkeri U,Mannikko M,et al.positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome.Mol Cell,1998,1(4):575-582. 被引量:1
  • 8Trygga K,Unraveling the mechanism of glomerular ultrafiltration:Nephrin,a key component of the slit diaphragm(J).J Am Soc Nephrol,1999,10(11):2440-2445. 被引量:1
  • 9Liu G,Kaw B,Kurfis J,et al.Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability.Clin Invest,2003,112(2):209-21. 被引量:1
  • 10Kawachi H,Koike H,Kurihara H,et al.cloning of rat homologue of podocin:expression in proteinuric states and in developing glomeruli.J Am Soc Nephrol,2003,14(1):46-56. 被引量:1

同被引文献23

  • 1HEERINGA S F,VLANGOS C N,CHERNIN G,et al.Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome[J].Nephrol Dial Transplant,2008,23(11):3527-3533. 被引量:1
  • 2KAUKINEN A,LAUTENSCHLAGER I,HELIN H,et al.Peritubular capillaries are rarefied in congenital nephrotic syndrome of the Finnish type[J].Kidney Int,2009,75(10):1099-1108. 被引量:1
  • 3KAUKINEN A,KUUSNIEMI A M,HELIN H,et al.Changes in glomerular mesangium in kidneys with congenital nephrotic syndrome of the Finnish type[J].Pediatr Nephrol,2010,25(5):867-875. 被引量:1
  • 4HUSSAIN S,ROMIO L,SALEEM M,et al.Nephrin deficiency activates NF-kappaB and promotes glomerular injury[J].J Am Soc Nephrol,2009,20(8):1733-1743. 被引量:1
  • 5MEGREMIS S,MITSIONI A,MITSIONI A G,et al.Nucleotide variations in the NPHS2 gene in Greek children with steroid-resistant nephrotic syndrome[J].Genet Test Mol Biomarkers,2009,13(2):249-256. 被引量:1
  • 6SUN H,ZHOU W,WANG J,et al.A novel mutation in NPHS2 gene identified in a Chinese pedigree with autosomal recessive steroid-resistant nephrotic syndrome[J].Pathology,2009,41(7):661-665. 被引量:1
  • 7FAN Q,ZHANG H,DING J,et al.R168H and V165X mutant podocin might induce different degrees of podocyte injury via different molecular mechanisms[J].Genes Cells,2009,14(9):1079-1090. 被引量:1
  • 8CARIDI G,GIGANTE M,RAVANI P,et al.Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations[J].Clin J Am Soc Nephrol,2009,4(6):1065-1072. 被引量:1
  • 9DANDAPANI S V,SUGIMOTO H,MATTHEWS B D,et al.Alpha-actinin-4 is required for normal podocyte adhesion[J].J Biol Chem,2007,282(1):467-477. 被引量:1
  • 10CHOI H J,LEE B H,CHO H Y,et al.Familial focal segmental glomerulosclerosis associated with an ACTN4 mutation and paternal germline mosaicism[J].Am J Kidney Dis,2008,51(5):834-838. 被引量:1

引证文献1

二级引证文献17

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部