摘要
目的了解G蛋白β3亚单位(GNB3)基因多态性与胸痹以痛患者情志的关系。方法用聚合酶链反应和限制性片段内切酶的方法检测27例胸痹以痛伴抑郁患者、40例胸痹以痛不伴抑郁患者及20例健康对照组的GNB3基因C825T多态性,用Zung量表评定抑郁。结果胸痹以痛抑郁发生率显著高于正常对照组(P<0.05),胸痹以痛抑郁组的GNB3基因825TT基因型及T等位基因频率高于胸痹以痛不抑郁组,差异有显著性(P<0.05或P<0.01)。结论GNB3基因多态性与胸痹以痛情志有一定的关联,尤其是GNB3825T等位基因在胸痹以痛抑郁情志的发生中可能起重要作用。
Objective To explore the relationship between polymorphism of G-protein β3 subunit （GNB3） gene and the emotion trait of chest stuffiness and pains patient. Methods The GNB3 gene type in 27 patients of depression of chest stuffiness and pains, 40 patients of no depression of chest stuffiness and pains, and 20 patients of healthy subjects （control） was determined by polymerase chain reaction and restriction fragment incision enzyme, and score of depression was evaluated. Result Occurrence of depression in chest stuffiness and pains was significantly higher than that in control （P〈0.05）. The 825TT gene type and T allele frequency of GNB3 was significantly higher in patients of depression of chest stuffiness and pains than that in no depression （P〈0.05 or P〈0.01）. Conclusion T allele frequency of GNB3 may be a important factor to depression of chest stuffiness and pains.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第11期23-26,共4页
Chinese Journal of Information on Traditional Chinese Medicine
基金
广东省中医药管理局科研立项课题(1050129)
关键词
胸痹心痛
抑郁
G蛋白Β3亚单位
多态性
chest stuffiness and pains
depression
G-protein β3 subunit
polymorphism
