摘要
冠心病和抑郁症在临床上有共同的风险机制,抑郁症会增加发生冠心病的风险,反之亦然,基因单核苷酸多态性可能与抑郁症合并冠心病的风险有关。目前候选共病基因包括5-HTT基因、APLN/APLNR基因、BDNF基因、ApoE基因、FKBP5基因、NR3C1、SGK1基因及PAI-1基因,临床上利用遗传信息可以预测疾病的发展,并且选择最有效的治疗措施,减少并发症。文章将从病理生理机制、基因多态性和基因多态性对中医药的影响角度对冠心病抑郁症共病进行综述,为临床研究提供依据。
Coronary heart disease and depression have a shared risk mechanism in clinical practice.Depression can increase the risk of coronary heart disease and vice versa.The gene single nucleotide polymorphisms may be related to the risk of depression combined with coronary heart disease.At present,candidate comorbid genes include 5-HTT gene,APLN/APLNR gene,BDNF gene,ApoE gene,FKBP5 gene,NR3 C1,SGK1 geneand PAI-1 gene.Clinically,genetic information can be used to predict the development of the disease and choose the most effective treatment to reduce complications.This article reviewed the comorbidities of coronary heart disease and depression from the perspective of pathophysiological mechanisms,gene polymorphisms,and the influence of gene polymorphisms on traditional Chinese medicine to provide a basis for clinical research.
作者
高璐
张哲
GAO Lu;ZHANG Zhe(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《实用中医内科杂志》
2021年第11期71-75,共5页
Journal of Practical Traditional Chinese Internal Medicine
基金
辽宁省重点研发计划(2020JH2/10300070)。
关键词
冠心病
抑郁症
基因多态性
单核苷酸多态性
中医药
coronary heart disease
depression
gene polymorphism
single nucleotide polymorphism
traditional Chinese medicine
