摘要
基底膜是一种特化的细胞外基质,是肿瘤转移过程中必须穿越的物理屏障。基底膜的组成成分通过和细胞表面受体整合素相互作用,在调节肿瘤转移的过程中发挥了重要作用。另一方面,肿瘤细胞通过分泌基质降解酶类破坏基底膜的组织结构,同时调节细胞外基质受体整合素的表达,为穿过基底膜和在靶器官粘附、增殖创造有利条件。了解细胞和基底膜的相互作用可以为抗转移药物的研发提供新的策略。
The basement membrane （BM） is a specialised form of extracellular matrix （ ECM）, which is a major barrier to tumor cells during metastasis. The component of basement membrane plays important role in regulating tumor metastasis by interacting with cell surface receptor integrins. On the other hand, tumor cells secrete Matrix metalloproteinase and Heparanase to degrade the extracellular matrix compo- nents, as well as adjust the expression of surface receptor-integrins to facilitate migration in basement membrane and adhesion to target organs. Understanding of the celI-ECM interaction may offer us new strategy for drug discovery.
出处
《生理科学进展》
CAS
CSCD
北大核心
2006年第4期307-312,共6页
Progress in Physiological Sciences
基金
国家自然科学基金资助课题(30228032)
