摘要
目的观察双氯芬酸二乙胺盐凝胶经皮用药的安全性。方法对家兔进行皮肤急性毒性实验、皮肤刺激性实验;对豚鼠进行皮肤变态反应实验。结果双氯芬酸二乙胺盐凝胶均未引起家兔毒性反应;对家兔完整皮肤无刺激作用,但对破损皮肤有轻度刺激作用;对豚鼠皮肤无致变态反应作用。结论双氯芬酸二乙胺盐凝胶经皮给药安全。
Objective To observe the safety of dielofenac diethylamine salt gel after external use. Methods Acute dermal toxicity test and dermal irritation test were conducted in rabbits, and dermal sensitivity test was performed in guinea pigs. Results Diclofenac diethylamine salt gel had no acute toxicity to the skin of rabbits with no stimulating action to the intact skin, but with a mild stimulation to the broken skin. Skin allergic reactions didn ＂t appear in guinea pigs. Conclusion Diclofenac diethylamine salt gel is safe for transdermal administration.
出处
《医药导报》
CAS
2006年第11期1116-1118,共3页
Herald of Medicine
关键词
双氯芬酸二乙胺盐
急性毒性
刺激性
变态反应性
Diclofenac diethylamine salt gel
Acute toxicity
Skin irritation
Skin allergy
