摘要
以苯甲醛为起始原料,首先制得肉桂酸,然后合成了5,7-二羟基黄烷酮,产率达91%,并利用IR、MS、1HNMR对其结构进行了表征和确认,同时还测试了产品的抑菌活性。生物测试结果表明,5,7-二羟基黄烷酮对大肠杆菌、枯草芽孢杆菌、金黄色葡萄球菌等具有优良的抑菌活性,在50μg/mL处理剂量下,对大肠杆菌、枯草芽孢杆菌的抑制率达100%。
5,7-Dihydroxy-flavanone was synthesized with cinnamic acid from benzaldehyde, whose yield amounted to 91%. Its structure was characterized and confirmed by IR, MS and ^1H NMR. Meanwhile, bactericidal tests have been carried out, and the results of preliminary biological test indicated that the compound has excellent bactericidal activities against Escherichia coli, Bacillus subtilis, staphylococcus aureus. The inhibition rate againsted Escherichia coli, Bacillus subtilis amounted to 100% at the dosage of 50μg/mL.
出处
《农药》
CAS
北大核心
2006年第11期733-734,736,共3页
Agrochemicals
关键词
5
7-二羟基黄烷酮
合成
抑菌活性
5,7-dihydroxy-flavanone
synthesis
bactericidal activity
