摘要
目的:监测我院病房分离的100株革兰阴性杆菌对12种抗生素的耐药率,以指导临床用药。方法:采用Etest药敏试验测定我院分离的100株革兰阴性杆菌对12种抗生素的最低抑菌浓度(MIC)。结果:这12种抗生素中总耐药率最低的是亚胺培南(7%),舒普深(8%),阿米卡星(12%),头孢吡肟(13%);49株大肠埃希菌及肺炎克雷伯菌中,超广谱β-内酰胺酶的发生率为43%;大肠杆菌对环丙沙星的耐药率高达76·5%;大肠埃希菌,肠杆菌属,不动杆菌,克雷伯菌属对亚胺培南的耐药率小于等于5·9%。结论:亚胺培南,舒普深,阿米卡星,头孢吡肟对革兰阴性杆菌的耐药率最低。
Objective： To investigate the resistant rate of gram - negative bacilli to 12 antibiotics isolated from the wards of West China Hospital. Method： E test was used to detect the minimal inhibition concentration of 100 gram- negative bacilli isolated from West China Hospital against 12 antibiotics. Results： Among 12 antibiotics, Imipenem, Cefopreazone sodium/Sulbactam, Amikacin, Cefepime had the lowest overall resistant rates of 7%, 8%, 12%, 13% respectively, The prevalence of extended spectrum β - lactamase was 43% in 49 E. coli and K. pneumoniae strains. 76.5% E. coli strains were resistant to Ciprofloxacin. The resistant rates of E. coli, Enterobacter, Acinetobacter, Klebsiella. spp to Imipenem was less than 5.9%. Conclusion： Imipenem, Cefopreazone sodium/Sulbactam, Amikacin, and Cefepime still the more effective antimicrobial agents to all gram- negative bacilli.
出处
《华西医学》
CAS
2006年第4期720-721,共2页
West China Medical Journal
关键词
耐药性
革兰阴性杆菌
医院感染
Resistance
Gram- negative bacilli
Nosocominal infections
