摘要
将注射成型的聚-L-乳酸/超细β-磷酸三钙(PLLA/超细β-TCP)复合材料圆棒(=4.0mm)分别在青紫蓝兔背部及37℃,pH值为7.4的磷酸盐缓冲液中进行12星期体内、外降解试验,研究了棒材的力学性能、PLLA的黏均分子量、复合棒材的重量和降解液的pH值随降解时间的变化,并采用扫描电镜对复合棒材降解样品的横截面及表面进行了表征。结果表明:体内降解速率明显快于体外降解;β-TCP粒子对PLLA的降解有明显的延缓作用;体内、外降解12星期后复合材料棒材的弯曲强度分别为106MPa、127MPa。
The vitro and vivo degradation behaviors of the poly （L-lactide）/ultrafine β-tricalcium phosphate composite are investigated. The 4 mm diameter rods prepared by injection moulding were tested with the rabbit and in a phosphate buffer saline at 37 ℃ and pH 7.4 for up to 12 weeks. The mechanical properties of the composite rods, the molecular weight of PLLA as well as the pH value of the phosphate buffer saline with the degradation time were studied. The morphology of the composite rods were also characterized by scanning electron micrograph. The results reveal that the composite rod can degrade considerably faster in vivo than in vitro. The weight loss of the composite rod lags behind the molecular weight loss evidently. β-TCP has significant inhibition effect on the degradation of PLLA. After 12 weeks degradation in vitro and in vivo, the bending strength of the composite rods remains 106 MPa and 127 MPa,respectively.
出处
《江苏科技大学学报（自然科学版）》
CAS
北大核心
2006年第5期76-80,共5页
Journal of Jiangsu University of Science and Technology:Natural Science Edition
基金
镇江市社会发展项目(2005CL010J)
江苏科技大学青年基金项目(2004CL015J)
