摘要
目的:测定老年慢性心力衰竭患者血浆尾加压素Ⅱ(U rotens inⅡ,UⅡ)的浓度,探讨血浆UⅡ水平与心功能的关系以及运动训练之影响。方法:分别测定118例心衰和48例非心衰病人以及30名正常人血浆UⅡ和脑钠肽(BNP)水平,对其进行相关比较。并在对心衰病人实施运动训练后,测定其治疗后血浆UⅡ和BNP水平,经心脏超声检测左室射血分数(LVEF)。结果:伴有心衰的心脏病患者血浆UⅡ水平(3.29±1.56 pg/m l)和不伴有心衰的心脏病患者血浆UⅡ水平(4.40±1.99 pg/m l)均明显低于正常人血浆UⅡ水平(7.55±1.62 pg/m l),P<0.05或P<0.01;心衰患者降低更为明显,并且随心功能不全的加重而下降(P均<0.01);血浆UⅡ水平与心功能分级和血浆BNP水平呈负相关(分别r=-0.313和r=-0.308,P<0.01),与LVEF呈正相关(r=0.304,P<0.05);训练组患者治疗后血浆UⅡ水平明显增加而血浆BNP水平则显著降低(P<0.01),与非训练组有显著差异(P<0.05)。结论:血浆UⅡ水平随心功能不全加重和血浆BNP水平的增加而降低,运动训练可升高血浆UⅡ水平,改善心功能。这提示血浆UⅡ水平可作为判断心衰严重程度和临床评价心衰治疗效果的生物学指标。
Objective： To observe the changes of plasma Urotensin Ⅱ （U Ⅱ ） and brain natriuretic peptide （BNP） in the aged patients with chronic heart failure （CHF）, and effect of exercise training on plasma U Ⅱ level. Methods： The levels of plasma U Ⅱ and BNP were determined by radioimmunoassay in 118 patients with CHF, 48 patients without heart failure and 30 control normal subjects. After treatments, the levels of plasma U Ⅱ and BNP levels were also observed between the patients with exercise training and without exercise training. Left ventricular fraction （LVEF） was measured by echocardiography in all subjects. Results： The plasma U Ⅱ level was significantly decreased in patients with CHF （3.29±1.59 pg/ml） and without heart failure （4.40±1.99 pg/ml） compared with control subjects （7.55±1.62 pg/ml）, P〈0.05 or P〈0. 01, The plasma U Ⅱ level was significantly lower in the patients with CHF than that of without CHF （P〈0. 05）. The decreased plasma U Ⅱ level were parallel with the severity of CHF. The plasma U Ⅱ level was negative correlation with cardiac function grade （r= —0. 313, P〈0.01） and the plasma BNP levels （r=—0. 308, P〈0. 01） . There was a significant positive correlation between plasma level of U Ⅱ and LVEF （r= 0. 304, P〈0.05） . Plasma U Ⅱ level increaced, plasma BNP level decreased after treatment in all patients; there were significantly different between the patients with exercise training and without exercise training （P〈0. 05）. Conclusion： The decreased plasma U Ⅱ level and the increased plasma BNP level were parallel with the severity of CHF. Exercise training can improve cardiac function, increase plasma U Ⅱ level. These results suggest that the plasma U Ⅱ level in CHF patients may serve as an index of the severity of CHF and the assessment for treatment effect.
出处
《心血管康复医学杂志》
CAS
2006年第5期424-426,423,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
首都发展基金项目(项目编号2002-3156)
关键词
心力衰竭
充血性
尾加压素Ⅱ
脑钠肽
运动疗法
Heart failure, congestive
UrotensinⅡ
Natriuretie peptide, brain
Exercise therapy
