摘要
本文对临床常规制片的54例正常结肠及结肠良恶性肿瘤组织切片进行银染核仁组织区技术(AgNOR染色)形态学定量观察,发现结肠腺上皮出现肿瘤性增生时,腺上皮细胞核的数量和AgNOR计数均明显增多;腺癌与绒毛状腺瘤在AgNOR颗粒的大小和形态方面均明显不同,但AgNOR计数并无显著差异。这提示对AgNOR颗粒大小,形态和计数分析,有助于鉴别诊断结肠腺瘤与腺癌,并且在探讨结肠腺瘤增生与癌变关系的机制方面亦有帮助。
By the use of silver colloid staining technique, nucleolar organizer region-associated proteins ( AgNORs ) were studied with quantitative methods in paraffin section of 22 colon adenocarcinomas, 12 polypoid adenomas, 10 papillary adenomas and 10 normal colonic mucosa as control. The results showed that the mean number of AgNORs per nucleus in the papillary adenomas was similar to that of adeno-carcinoma, which significantly exceeded that of the normal mucosa and the polypoid adenoma. The granules of AgNORs in adenocarcinoma were much larger and more irregular in size and shape. It is suggested that benign papillary adenoma is a kind of lesion between polypoid adenoma and adenocarcinoma, and AgNORs technique may be very helpful in the differential diagnosis of colon tumors.
出处
《第一军医大学学报》
CSCD
1990年第1期28-31,共4页
Journal of First Military Medical University
关键词
核仁组织区
结肠癌
形态学
nucleolar organizer regions ( NORs )
colon carcinoma
polypoid adenoma
papillary adenoma
histochemistry
