摘要
研究碳亲核试剂(2a～2e)与手性合成砌块,5-孟氧基-3-溴-2(5H)-呋喃酮的不对称串联反应,分别得到不同结构的光学活性化合物3a～3d,4,5和6.通过X射线晶体分析确认了它们的立体化学结构.
The structurally different chiral compounds 3a-3d, 4, 5 and 6 with newly formed stereogenic centers were obtained via the tandem asymmetric Michael addition and internal nucleophilic substitution reaction of 3-bromo-2,5-dihydro-5-menthyloxyfuran-2-one with different carbon nucleophiles. The chemical structures of these complicated compounds were determined by analytical and spectroscopic data. The proposed structures were confirmed by the X-ray crystallographic analysis of 3a （S）, 5 and 6.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2006年第19期2008-2014,共7页
Acta Chimica Sinica
基金
国家自然科学基金(No.29672004)资助项目.
关键词
不对称串联反应
碳-碳键形成
光学活性
晶体结构
tandem asymmetric reaction
carbon-carbon bond formation
optical activity
crystal structure
