摘要
目的:研究三七总皂甙联合慢作用抗风湿药甲氨蝶呤及柳氮磺吡啶改善类风湿关节炎关节症状的疗效。方法:62例患者随机分入治疗组和对照组,治疗组(n=32)采用三七总皂甙+甲氨蝶呤+柳氮磺吡啶治疗,对照组(n=31)采用甲氨蝶呤+柳氮磺吡啶治疗,比较两组患者关节疼痛指数、压痛指数、肿胀指数及血沉、C反应蛋白、类风湿因子、血小板的改善情况。结果:治疗20天后,治疗组关节疼痛指数、关节压痛指数、关节肿胀指数、血沉及C反应蛋白等指标改善情况优于对照组(P>0.05)。结论:三七总皂甙+甲氨蝶呤+柳氮磺吡啶在短期内改善活动性类风湿关节炎患者的关节症状效果较好。
Objective： To observe the effect of improving symptom of joint for combination therapy of Panax notoginseng saponins （PNS） and methotrexate （MTX） and sulfasalazine （SASP） in patients with active rheumatoid arthritis （RA）. Method： Sixty- three RA patients were randomized into therapy group （PNS ＋ MTX ＋ SASP, n = 32） and control group （MTX＋SASP, n=31）. Painful joint index, tender joint index, swollen joint index, erythrocyte sedimentation rate （ESR）, C - reactive protein （CRP）, rheumatoid factor （RF） and platelet were observed. Result： Compared with the control group, the PNS group had a superior improvedment in the painful joint index, tender joint index, swollen joint index, ESR and CRP （ P 〈 0.05） after 20 - day treatment. Conclusion： Combination therapy of PNS, MTX and SASP is effective for improving symptom of joint in patients with active RA in the near future.
出处
《云南中医学院学报》
2006年第5期32-34,共3页
Journal of Yunnan University of Traditional Chinese Medicine
关键词
类风湿关节炎
三七总皂甙
Rheumatoid Arthritis
Panax Notoginseng Saponins
