摘要
心律失常合并心力衰竭应用普罗帕酮(Propafenone,PF)治疗有时需与地高辛(Digoxin,D)合用。关于两药在人体内的双重相互作用(Double interaction)国内外尚未见报道。本文利用荧光偏振免疫分析法和反相高效液相色谱法测定了12名健康志愿者两药单用和合用时体内的血药浓度变化和药动学参数,同时行心电圈监护和测定心率、血压,并记录受试者的主诉反应,首次得到了中国人两药合用时相互作用的资料。结果表明,两药合用时,血清D浓度平均升高31.57％(P<0.01)。个别受试者血压明显下降、心电图ST段下移。PF的血浓度和药物动力学参数与单用时相比无显著性变化(P>0.05)。
The double drug interaction between propafenone (PF) and digoxin (D) was investigated in twelve healthy volunteers. The subjects were randomly divided into two subgroups and each group received PF, D, PF plus D at different administration plan, respectively. The serum D concentration (SDC) and plasma PF concentration (PPFC) were measured by fluorescence polarization immunoas-say (FPIA) and high performance liquid chromatography (HPLC), respectively. The concentration -time data of PF were inputted into an IBM/PC/XT microcomputer. The MCPKP - automatic pharmacokinetic program (worked out by Xia WJ) was employed for selection of the optimal compartment model and calculation of the pharmacokinetic parameters using weighted nonlinear least square regression.The results of this study showed that SDC (mean±SD) rose from 0.64±0.14 ng/ml to 0.83±0.17 ng/ml (mean increase 31.57±20.81%, P<0.01) during PF administratioa The concentration and pharmacokinetic parameters of PF were not affected by D (P>0.05), but there was great interindivi-dual variability. Although no normal man had serious adverse effects from the PF plus D interaction, in patients receiving D and PF simultaneously, the SDC should be monitored and the dosage of D readjusted if there is evidence of toxicity.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第4期309-314,共6页
Academic Journal of Second Military Medical University
基金
第二军医大学青年科研基金
关键词
普罗帕酮
地高辛
药物相互作用
propafenone
digoxin
interaction
pharmacokinetics
pharmacodynamics
